CDI Vol 28 No 2
نویسندگان
چکیده
Reports of six deaths internationally, including one from Australia, plus other cases of severe systemic adverse events following yellow fever (YF) vaccination have raised concern about the safety of YF vaccine, particularly among older vaccinees. We investigated the age-related reporting rates of adverse events following YF vaccination reported to the Australian Adverse Drug Reactions Advisory Committee for the period 1993 to 2002. The reporting rate of systemic adverse events leading to hospitalisation or death was signifi cantly higher among vaccinees aged ≥65 years [reporting rate ratio (RRR) 8.95, 95% confi dence interval (CI) 1.49–53.5] or ≥45 years (RRR 5.30, 95% CI 1.33–21.2) compared with younger YF vaccinees. The higher reporting rates among older vaccinees are similar to those identifi ed in the United States of America. The data highlight the importance of assessing the destination-specifi c risk, especially for older travellers to yellow fever endemic areas, and careful monitoring of those who are vaccinated. Commun Dis Intell 2004;28:244–248.
منابع مشابه
Severe clinical outcome is uncommon in Clostridium difficile infection in children: a retrospective cohort study
BACKGROUND Clostridium difficile infection (CDI) is the most common cause of health care-associated diarrhea in children and adults. Although serious complications of CDI have been reported to be increasing in adults, this trend has not yet been demonstrated in children. The purpose of this study was to examine the features of CDI in a pediatric population, with special attention to the occurre...
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BACKGROUND Efforts to develop a Clostridium difficile vaccine are underway; identification of patients at risk for C. difficile infection (CDI) is critical to inform vaccine trials. We identified groups at high risk of CDI ≥ 2 8 days after hospital discharge. METHODS Hospital discharge data and pharmacy data from two large academic centers, in New York and Connecticut, were linked to active p...
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